Obesity and Cancer

Obesity and cancer.

“Epidemiological studies have suggested that obesity is associated with increased risk of several cancer types including colon, esophagus, breast (in postmenopausal women), endometrium, kidney, liver, gallbladder and pancreas.”

Exp Clin Endocrinol Diabetes. 2009 Nov;117(10):563-6.

Green tea cancer prevention

Green tea (Camellia sinensis) for the prevention of cancer

Green tea contains catechins which are powerful antioxidants that may prevent cancer. This Cochrane review looked at 51 studies that included:

  • cancer of the digestive tract,
  • breast cancer,
  • prostate cancer,
  • lung cancer,
  • ovarian cancer,
  • oral cancer.

Drinking 3 to 5 cups of green tea per day is safe and provides 250 mg of catechins per day.
The author concludes that there is insufficient evidence for green tea consumption preventing cancer.

Cochrane Database Syst Rev. 2009 Jul 8;(3):CD005004.

Aspirin and NSAIDs for cancer prevention

Aspirin and non-steroidal anti-inflammatory drugs for cancer prevention: an international consensus statement

Aspirin and non-steroidal anti-inflammatory drugs (NSAIDs) could prevent colorectal cancer and may probably prevent other cancers. Research is focusing on breast, prostate, lung, stomach, and oesophageal cancer.

Lancet Oncol. 2009 May;10(5):501-7

Energy intake, physical activity and cancer

Energy intake, physical activity, energy balance, and cancer: epidemiologic evidence.

Obesity increases the risk of cancers of

  • colon and rectum
  • breast (in postmenopausal women)
  • endometrium (lining of the uterus)
  • kidney (renal cell)
  • esophagus (adenocarcinoma).

Obesity probably increases cancers of

  • pancreas
  • liver
  • gallbladder
  • aggressive prostate cancer.
Methods Mol Biol. 2009;472:191-215.

Causes of esophageal cancer

Environmental causes of esophageal cancer.

Gastroesophageal reflux, obesity, tobacco smoking, hiatal hernia, achalasia, and, probably, absence of H pylori in the stomach increase the risk of esophageal adenocarcinoma.

Gastroenterol Clin North Am. 2009 Mar;38(1):27-57, vii.

Diet and cancer chemoprevention

Dietary factors and cancer chemoprevention: an overview of obesity-related malignancies.

“Currently, obesity-related malignancies, e.g., cancers of the breast, prostate and colon are the leading cancers in the industrialized societies.”

This review looks at cancer prevention studies in selected cancers associated with obesity:

  • Prostate cancer
  • Breast cancer
  • Endometrial cancer
  • Kidney cancer
  • Esophageal adenocarcinoma
  • Colon cancer

And on foods that have anti-obesity and anti-cancer effects:

  • Garlic
  • Fenugreek
  • Green tea
  • Soy
  • Bitter melon
  • Plant defense molecules
  • Fish
Murthy NS, Mukherjee S, Ray G, Ray A.
J Postgrad Med. 2009 Jan-Mar;55(1):45-54. Review.

Wood Dust Causes Cancer

Wood dust exposure and the risk of upper aero-digestive and respiratory cancers in males.

Wood dust is a human carcinogen that can cause sino-nasal cancers.
This study also shows that wood dust exposure is a potential risk factor for upper aero-digestive tract and respiratory cancers

Occup Environ Med. 2008 Oct;65(10):647-54. Epub 2008 Jan 8.

Diet and upper-aerodigestive tract cancer

Diet and upper-aerodigestive tract cancer in Europe: The ARCAGE study.

Eating red meat increased upper-aerodigestive tract cancer risk, especially esophageal cancer.
The consumption of fruits, vegetables, olive oil and tea reduced the risk of upper-aerodigestive tract cancer.

Int J Cancer. 2008 Dec 23.